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# RadExIORSBoost: RadExIORSBoost aims to investigate individual radiosensitivity of prostate cancer patients under radiation treatment

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## Posts
- [Science Day, Botanical Garden “Jevremovac”, 11 July 2026](https://radexiorsboost.com/science-day-botanical-garden-jevremovac-11-july-2026/): The RadExIORSBoost project team members, Nina Petrović, Nađa Grozdanić Stanisavljević, and Ivana Matić, stepped into the roles of scientific demonstrators at the exhibition of the Serbian Association for Cancer Research (SDIR) celebrating National Science Day in Serbia. This scientific event was organized by the Center for Scientific Research of Students of the Faculty of Biology (CNIRS) at the Botanical Garden "Jevremovac", surrounded by astonishing biodiversity, plants, trees, and a great scientific atmosphere.
- [RadExIORSBoost Radiobiology School, Medical Faculty Mannheim, Heidelberg University, 8-10 July 2026](https://radexiorsboost.com/radexiorsboost-radiobiology-school-medical-faculty-mannheim-heidelberg-university-8-10-july-2026/): The First RadExIORSBoost Radiobiology School titled “Radiobiology and RadExIORSBoost WP2 work in progress" was successfully held from 8 to 10 July 2026 at the University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University. Members of the IORS team – Dr. Ivana Matić, Dr. Nina Petrović, Dr. Aleksandar Stepanović, Dr. Katarina Kopčalić, Ivana Pašić and Maja Petrović, participated together with Prof. Dr. Maja Čemažar, Prof. Dr. Gregor Serša, Lara Snoj, Veronika Škrjanc (OI LJUBLJANA), Prof. Dr. Christopher Talbot,  Dr. Tim Rattay (ULEIC), Prof. Dr. Marlon Veldwijk, Prof. Dr. Carsten Herskind, Ahmad Šami, Dr. Barbara Link, Dr. Michael Ehmann (UHEI), Dr. Miroslav Mišík (MUW), and other project colleagues who joined the event online.
- [RadExIORSBoost Project Workshop 8, Medical Faculty Mannheim, Heidelberg University 6-8 July 2026](https://radexiorsboost.com/radexiorsboost-project-workshop-8-medical-faculty-mannheim-heidelberg-university-6-8-july-2026/): RadExIORSBoost project team members attended "Workshop on the bioinformatical and biostatistical analysis of RNA-seq data" at the Medical Faculty Mannheim, Heidelberg University from 6-8 July 2026. Workshop gathered onsite team members from the Institute for Oncology and Radiology of Serbia (Dr. Nina Petrović and Dr. Ivana Matić), members from the Institute of Oncology Ljubljana (Lara Snoj and Veronika Škranjc), member from the University of Leicester (Dr. Adam Webb), and host team from the Medical Faculty Mannheim (Ahmad Šami, Dr. Marlon Veldwijk, and Dr. Barbara Link). Through excellent presentations and practical training led by Mr. Šami and Dr. Webb workshop participants successfully completed analysis on RNA sequencing data and gained new knowledge in biostatistics and bioinformatics.
- [RadExIORSBoost project training and short-term training visit, University of Leicester, Leicester, May 2026](https://radexiorsboost.com/radexiorsboost-project-training-and-short-term-training-visit-university-of-leicester-leicester-may-2026/): The fifth RadExIORSBoost project training titled “Radiogenomics and basic principles of machine learning models in radiobiology” was successfully held from 18 to 20 May 2026 at the University of Leicester, United Kingdom. The training organized in a form of hybrid event  gathered project team members from the Institute for Oncology and Radiology of Serbia (Dr. Ivana Matić, Dr. Nina Petrović, Dr. Marina Popović Krneta, and Dr. Branislava Gemović), Medical Faculty Mannheim, Heidelberg University (Prof. Dr. Marlon Veldwijk and Ahmad Šami), Institute of Oncology Ljubljana (Dr. Barbara Lisec) and host team from the University of Leicester led by Prof. Dr. Christopher Talbot (Prof. Dr. Christopher Talbot, Dr. Adam Webb, Dr. Tim Rattay,  Dr. Bo Wang, and Prof. Dr. Huiyu Zhou).
- [RadExIORSBoost project workshop 7 “DNA Damage and Genotoxicity Testing in Cancer Risk Assessment”, Medical University of Vienna, 4-8 May 2026](https://radexiorsboost.com/radexiorsboost-project-workshop-7-dna-damage-and-genotoxicity-testing-in-cancer-risk-assessment-medical-university-of-vienna-4-8-may-2026/): The RadExIORSBoost team members from the Institute for Oncology and Radiology of Serbia (Dr. Tatjana Stanojković, Dr. Nina Petrović, and Dr. Ivana Matić) and from the Institute of Oncology Ljubljana (Dr. Tina Kos and Dr. Maša Omerzel) participated in a project workshop 7 titled “DNA Damage and Genotoxicity Testing in Cancer Risk Assessment”, organized from 4-8 May 2026 at the Center for Cancer Research, Medical University of Vienna.
- [Prof. Dr. Marina Nikitović received the prestigious “Despot Stefan Lazarević” award](https://radexiorsboost.com/prof-dr-marina-nikitovic-received-the-prestigious-despot-stefan-lazarevic-award/): We are pleased to announce that Prof. Dr. Marina Nikitović, a member of the RadExIORSBoost project team and Work Package Leader, is the recipient of the prestigious “Despot Stefan Lazarević” Award, a City of Belgrade award granted for outstanding achievements and contributions to the advancement of medicine.
- [Short-term training visit of the IORS team members at the Institute of Oncology Ljubljana](https://radexiorsboost.com/short-term-training-visit-of-the-iors-team-members-at-the-institute-of-oncology-ljubljana-2/): Radiation oncologists Asst. Prof. Aleksandar Stepanović, MD, PhD, and Katarina Kopčalić, MD, PhD, Research Associate, members of the RadExIORSBoost project team, successfully completed the Workshop on Clinical Research at the Institute of Oncology Ljubljana, as a part of their short-term training visit from 16 March to 20 March 2026. The workshop provided practical knowledge on clinical research fundamentals, including clinical study design, protocol development, and key ethical and regulatory principles such as Good Clinical Practice and data protection.
Such advanced training plays an important role in strengthening the competencies of the entire RadExIORSBoost project team and fostering high-quality collaborative research.
RadExIORSBoost team sincerely thanks Prof. Maja Čemažar, Dr. Barbara Bonač Tuma, and Assist. Neža Gros for the excellent organization and insightful training.
- [Professor Marina Nikitović’s interview on the RTS News on 13 March 2026](https://radexiorsboost.com/professor-marina-nikitovics-interview-on-the-rts-news-on-13-march-2026/): Prof. Marina Nikitović, a distinguished member of the RadExIORSBoost project team and a Deputy Director for Research and Education of the Institute for Oncology and Radiology of Serbia, appeared as a guest on the national Radio-Television of Serbia news program on 13 March 2026.
During the interview, Prof. Nikitović talked about the main concept, objectives, and key activities of the RadExIORSBoost Horizon Europe project, which is dedicated to establishing personalized radiotherapy and advancing research integration into clinical practice. She highlighted the importance of predicting normal tissue reactions to radiotherapy in patients with prostate cancer, which is essential for the development of a personalized radiotherapy approach in the future and the improvement of the quality of life of cancer patients treated with radiotherapy.
The RadExIORSBoost project team thanks Prof. Marina Nikitović for her excellent interview.
- [The Fourth RadExIORSBoost Educational Seminar for cancer patients treated with radiotherapy](https://radexiorsboost.com/the-fourth-radexiorsboost-educational-seminar-for-cancer-patients-treated-with-radiotherapy/): At the beginning of March, a month dedicated to the fight against cancer in Serbia, the RadExIORSBoost Horizon Europe project team welcomed cancer patients to the fourth educational seminar titled “Personalized approach in radiotherapy: From science to the clinic” at the new amphitheater of the Institute for Oncology and Radiology of Serbia (IORS). The seminar was organized in collaboration with the Serbian Society for the Fight Against Cancer and the Working Group for Patient Support of the Institute for Oncology and Radiology of Serbia.
Patients from the IORS learned about the basic principles of modern radiation therapy, acute and late adverse reactions to radiotherapy, the important facts they need to know during their treatment, the significance of the psychological support for cancer patients, different activities and forms of patients’ support of the IORS Working Group for Patient Support, as well as about key biological factors underlying normal tissue reactions to radiotherapy. The patients had the opportunity to learn about the radiobiology research of the RadExIORSBoost project team and their efforts towards identifying possible predictors of radiosensitivity, which are essential to establishing a personalized radiotherapy approach in the future.
The event ended with a discussion between the cancer patients and the lecturers, who addressed all the questions and concerns of the patients undergoing radiotherapy. The success of the seminar highlighted the benefits of attending educational events for the cancer patients.
The RadExIORSBoost project team would like to thank the patients and lecturers, Dr. Aleksandar Stepanović, Dr. Katarina Kopčalić, Dr. Ivana Matić, Dr. Marija Andrijić, and Dr. Ana Jovićević, as well as the seminar moderators, Prof. Dr. Marina Nikitović and Dr. Tatjana Stanojković. FULL PROGRAM
- [Nina Petrović. Key points on writing an effective literature review article: A review of a review. Oncology Insights No.3. 2025.ISSN 3009-3848. p:31-35.](https://radexiorsboost.com/nina-petrovic-key-points-on-writing-an-effective-literature-review-article-a-review-of-a-review-oncology-insights-no-3-2025-issn-3009-3848-p31-35/): https://www.sdir.ac.rs/arhiva/2025/no3/#p=46
- [Short-term training visit of the IORS team members at the Institute of Oncology Ljubljana](https://radexiorsboost.com/short-term-training-visit-of-the-iors-team-members-at-the-institute-of-oncology-ljubljana/): In parallel with our latest workshop, the RadExIORSBoost project team members, Dr. Nina Petrović, Dr. Nađa Grozdanić Stanisavljević, Dr. Tatjana Stanojković, and Dr. Ivana Matić, conducted a short-term training visit at the Institute of Oncology Ljubljana from 2 February to 6 February 2026. This training visit provided participants with intensive, hands-on experience in advanced molecular and cellular biology techniques. The visit was designed to mirror a complete experimental pipeline, guided by the experts in the field: Dr. Urška Kamenšek, Dr. Barbara Lisec, Dr. Maša Omerzel, and Dr. Boštjan Markelc.
- [RadExIORSBoost Project Workshop 6, 2-6 February 2026, Ljubljana, Slovenia](https://radexiorsboost.com/radexiorsboost-project-workshop-6-2-6-february-2026-ljubljana-slovenia/): The RadExIORSBoost project team members participated in Workshop 6, held from 2-6 February 2026. Hosted at the Institute of Oncology Ljubljana in Slovenia, this hybrid scientific event  focused on the topic: “Radiosensitisation of malignant tumors with electroporation-based therapies”.
- [Radiobiologija u medicini i nauci: biološki odgovor na jonizirajuće zračenje](https://radexiorsboost.com/radiobiologija-u-medicini-i-nauci-bioloski-odgovor-na-jonizirajuce-zracenje/): Зрачење представља емитовање енергије у виду честица или таласа. Зрачење може бити јонизујуће или нејонизујуће природе. Јонизујуће зрачење је тип зрачења ниске таласне дужине, самим тим високе фреквенције и енергије. До јонизације средине кроз коју пролазе доводе алфа, бета таласи и неутрони који су честичне природе и гама зраци који су по природи таласи. Сви наведени типови зрачења спадају у радиоактивно зрачење. У јонизујуће зрачење спадају и Xзраци који нису радиоактивног карактера, али јонизују средину кроз коју пролазе. Због своје високе енергије и продорне моћи, јонизујуће зрачење доводи до стварања оштећења како на ћелијским структурама као што су рибозоми, ћелијска мембрана, ендоплазматични ретикулум или на органелама као што су митохондфије, који су неопходни за правилно функционисање ћелије, тако и на молекулским структурама протеина, масти, ДНК и РНК. Када јонизујуће зрачење дође у контакт са ДНК молекулом, за који знамо да је дволанчани хеликс редоследа нуклеотида, може да доведе до једноланчаних и дволанчаних прекида, што за последицу има активацију механизама за поправку оштећења ДНК или покреће различите типове ћелијске смрти, као што су ћелијска смрт по принципу апоптозе, некрозе, аутофагије, пироптозе или фероптозе.... Petrović, Nina. ‘Radiobiologija U Medicini I Nauci: Biološki Odgovor Na Jonizirajuće Zračenje’. RAK. Časopis Društva Za Borbu Protiv Raka 2025, no. 136 (June 2025): 15–17. https://doi.org/10.5281/zenodo.18390297.
- [Biološki faktori individualne osetljivosti na radioterapiju](https://radexiorsboost.com/bioloski-faktori-individualne-osetljivosti-na-radioterapiju/): Током зрачења малигног тумора мали волумен околног, здравог, нетрансформисаног ткива се налази у пољу зрачења, што код пацијената може да доведе до појаве акутних и касних нежељених ефеката. Код 5% до 10% пацијената са малигним обољењима који се лече радиотерапијом може да дође до појаве нежељених ефеката вишег градуса, који значајно могу да утичу на квалитет живота. Велики број фактора утиче на ризик за појаву нежељених ефеката радиотерапије: физички параметри, као што су доза зрачења, доза по фракцији, број фракција и волумен озраченог ткива, затим бројни индивидуални, клинички и биолошки фактори, попут генетичких и епигенетичких фактора, медијатора инфламације и имунског одговора. Један од највећих изазова у савременој радијационој онкологији је да се развију предиктивни модели за процену ризика за настанак нежељених ефеката радиотерапије пре почетка зраче ња, а који би омогућили прилагођавање радиотерапије сваком пацијенту и свели радијациону токсичност на минимум. Стога је откриће биолошких предиктора одговора нормалног ткива на зрачење, односно процена индивидуалне радиосензитивности нормалног ткива од изузетног значаја и представља један од примарних циљевa истраживања у радиобиологији. Matić, Ivana Z. ‘Biološki Faktori Individualne Osetljivosti Na Radioterapiju’. RAK. Časopis Društva Za Borbu Protiv Raka 2025, no. 136 (June 2025): 18–22. https://doi.org/10.5281/zenodo.18390464.
- [Najčešća pitanja pacijenata koji se leče radioterapijom](https://radexiorsboost.com/najcesca-pitanja-pacijenata-koji-se-lece-radioterapijom/): Реализација идеје да се одржи едукативни семинар у којем су лекари, истраживачи и остали чланови RadExIORSBoost тима сажето покушали да појасне радиотерапијске технике зрачења, нежељене ефекте радиотерапије, значај психолошке подршке пацијентима оболелим од малигних болести и њиховим породицама, везу између медицине и науке, као и приказ рада Радне групе за подршку пацијентима и приказ рада Друштва Србије за борбу против рака, показала се веома успешном и корисном.
- [Neželjeni efekti radioterapije](https://radexiorsboost.com/nezeljeni-efekti-radioterapije/): Значајан напредак у раном откривању, дијагностици и лечењу малигних болести довео је до све већег броја пацијената који постижу дуготрајну ремисију или се сматрају излеченима. Савремене терапије, укључујући хирургију, радиотерапију, хемиотерапију, као и циљану и имунотерапију, допринеле су продужењу животног века. Међутим, продужени животни век доноси и нове изазове – све више пацијената суочава се са касним компликацијама терапије, што може утицати на квалитет живота. Због тога савремени приступ у лечењу малигних болести захтева шири и дугорочнији концепт – циљ није само ремисија или излечење, већ и обезбеђивање квалитетног и достојанственог живота након лечења. Препознавање, праћење и управљање касном токсичношћу постају неизоставни део онколошке доктрине. Такође, познавање уче сталости и тежине компликација сваког терапијског модалитета кључно је за избор оптималног, индивидуализованог лечења које узима у обзир не само здравствено стање, већ и животне околности и личне преференције пацијента, што чини основу персонализоване медицине. Stanić, Jelena D., and Marina Nikitović. ‘Neželjeni Efekti Radioterapije’. RAK. Časopis Društva Za Borbu Protiv Raka. 2025, no. 136 (June 2025): 7–11. https://doi.org/10.5281/zenodo.18389584.
- [Savremena radioterapija u lečenju malignih bolesti](https://radexiorsboost.com/savremena-radioterapija-u-lecenju-malignih-bolesti/): Радиотерапија или зрачна терапија подразумева примену високоенергетског јонизујућег зрачења (нпр. Х, гама зрачење) у лечењу, првенствено малигних болести, али се користи и у лечењу појединих бенигних обољења и стања. У зависности од врсте тумора, стадијума болести, локализације болести и одређених прогностичких фактора, радиотерапију у лечењу малигних болести можемо користити као куративну (радикалну), адјувантну и палијативну радиотерапију. Основна тежња радикалне радиотерапије је да се потпуно уништи популација туморских ћелија. Циљ адјувантне радиотерапије је ерадикација (елиминација) преосталих туморских ћелија (нпр. након операције, када се назива и постоперативна радиотерапија), док су код палијативне радиотерапије основни циљеви ублажавање симптома болести и побољшање квалитета живота. Од када је примена радио- терапије у употреби као модалитет онколошког лечења, основна сврха је била увек иста, а то је уништава- ње ћелија тумора уз максималну поштеду и адекватну заштиту окол- них, тумором незахваћених ткива и органа. Одлука о избору оптималног модалитета зрачења (примена кон- венционалне или неке од савреме- них техника радиотерапије), мора се доносити индивидуално за сваког пацијента у зависности од врсте и карактеристика примарног тумора, стадијума болести и општег стања пацијента.
- [RadExIORSBoost Exploring Individual Radiosensitivity: A Voyage Through RNA and miRNA Universe](https://radexiorsboost.com/radexiorsboost-exploring-individual-radiosensitivity-a-voyage-through-rna-and-mirna-universe/): Abstract:The main goal of radiation oncology is to deliver the proper dose as precisely as possible to the desired site, to inhibit the division of canceror residual cancer cells, and to induce predominantly apoptotic cell death. Another goal is to spare surrounding non-malignantly transformed tissue (1). In the field of radiobiology that investigates normal tissue radiosensitivity, a wide spectrum of biological and functional tests have emerged as candidates for the prediction of normal tissue radiosensitivity and adverse effects, which may considerably affect patients' quality of life. Adverse effects following prostate cancer (PCa) radiotherapy (RT) include bladder and urinary complications (2), as well as rectal toxicity (3), among others. It has been shown that the transcriptome and miRNome change after radiation exposure, as well as signaling pathways.The most commonly affected biological pathways by radiation exposure are those associated with DNA damage repair, inflammation, oxidative stress, cell regulation, and apoptosis (4).
- [Investigation of individual radiosensitivity of prostate cancer patients under radiation treatment](https://radexiorsboost.com/investigation-of-individual-radiosensitivity-of-prostate-cancer-patients-under-radiation-treatment/): Radiotherapy plays a central role in the treatment of patients with prostate cancer. One of the main challenges inmodern radiation oncology is to develop efficient predictive models for the estimation of the radiation toxicity riskto tailor radiation treatment to the ndividual patient, improve the therapeutic success, and minimize severe adverseeffects in cancer survivors. Numerous treatment-related, patient-specific, clinical, and biological factors, includinggenetic and epigenetic factors, as well as mediators of inflammation and immune response, may affect the possiblerisk of developing acute and late genitourinary and gastrointestinal radiation toxicity in prostate cancer patientsundergoing radiotherapy. The multifactorial biological background of each cancer patient is responsible for individualdifferences in radiation-induced normal tissue toxicity. The investigation of the sensitivity of patient-derived peripheralblood mononuclear cells (PBMC) to ionizing radiation using different cell-based functional assays in combinationwith molecular mechanisms underlying this signature and specific acute and late radiation toxicity adverse eventsin prostate cancer patients using genomic, transcriptomic, epigenomic, and proteomic profiling is essential foridentification of novel biomarkers and models for individual radiosensitivity assessment. The radiobiology researchconducted within the Horizon Europe Twinning project RadExIORSBoost at the Institute for Oncology and Radiology ofSerbia (coordinator) in collaboration with top-class leading European research institutions...
- [Use of Genotoxicity Methods for Human Biomonitoring: Prevention – Diagnosis and Therapy of Cancer](https://radexiorsboost.com/use-of-genotoxicity-methods-for-human-biomonitoring-prevention-diagnosis-and-therapy-of-cancer/): A variety of different methods have been used to investigate the radiosensitivity of cancer patients treated with radiotherapy in order to predict the risk for developing adverse effects, improve the therapeutic success, and patient’s quality-of-life.The most investigations were realised with peripheral blood cells from head and neck cancer, breast cancer, and prostate cancer patients. The irradiation response of patient-derived lymphocytes has been associated with acute and late normal tissue reactions to radiotherapy. The approaches which were used include measurements of cytotoxic effects (including apoptosis and cell cycle delay), identification and analyses of specific genes and use of methods which reflect genotoxicity and DNA repair. The most frequently employed approaches that detect damage of the genotoxic material which is induced by ionizing radiation (double strand breaks and oxidative damage) are chromosomal aberration (CA) analyses of metaphase cells, micronucleus (MN) experiments detecting structural and numerical CA, γH2AX assays which can be used to measure double strand breaks, and single cell gel electrophoresis (SCGE) assays reflecting single and double DNA strand breaks . Individual differences in the repair capacity were mainly studied in SCGE experiments in which the time kinetics of the disappearance of “comets” was measured. Overall the results of these studies are highly controversial, possibly due to inconsistent experimental designs and methodological shortcomings (including small study groups)...
- [RadExIORSBoost Project Training “How to budget EU proposals, pre-award phase”, 8-9 December 2025, Belgrade](https://radexiorsboost.com/radexiorsboost-project-training-how-to-budget-eu-proposals-pre-award-phase-8-9-december-2025-belgrade/): The RadExIORSBoost Horizon Europe Project team successfully organized training ”How to budget EU proposals, pre-award phase” at the Institute for Oncology and Radiology of Serbia from 8 to 9 December 2025.
- [RadExIORSBoost project team in a visit to the Elementary School “Vuk Karadžić”](https://radexiorsboost.com/radexiorsboost-project-team-in-a-visit-to-the-elementary-school-vuk-karadzic/): The RadExIORSBoost project team members visited enthusiastic scholars in the 6th grade at the Elementary School “Vuk Karadžić” in Belgrade on 26 November 2025.
- [The Third RadExIORSBoost Educational Seminar for cancer patients treated with radiotherapy](https://radexiorsboost.com/the-third-radexiorsboost-educational-seminar-for-cancer-patients-treated-with-radiotherapy/): The RadExIORSBoost Twinning Horizon Europe Project team organized the third educational seminar for patients with malignant diseases titled “Personalized approach in radiotherapy: From science to the clinic” in the amphitheater of the Institute for Oncology and Radiology of Serbia (IORS) on 26 November 2025. Patients with prostate cancer treated with radiotherapy at the IORS had the opportunity to learn about the radiation therapy techniques, possible normal tissue reactions to radiotherapy, the importance of the psychological support for cancer patients, the history and activities of the Serbian Society for the Fight Against Cancer and the IORS Working Group for Patient Support, as well as about the biological response to radiation and the most important biological factors underlying individual normal tissue radiosensitivity important for personalized radiotherapy approach in the future. The prostate cancer patients received answers to the most frequently asked questions that may arise during radiotherapy.
- [RadExIORSBoost team members at the 62nd Oncology Congress, 14 November 2025](https://radexiorsboost.com/radexiorsboost-team-members-at-the-62nd-oncology-congress-14-november-2025/): Members of the RadExIORSBoost Project team, Prof. Dr. Marina Nikitović and Dr. Tatjana Stanojković, successfully organized and coordinated a session entitled “From 3D-CRT, IMRT, and VMAT to Proton and Hadron Therapy: Shaping the Future of Radiotherapy” at the 62nd Oncology Congress on 14 November 2025 at the Sava Center in Belgrade, Serbia. Invited speakers were Aleksandar Stepanović, Angelica Facoetti (Italy), Mark Pleško (Slovenia), Jelena Bokun, Nina Petrović, and Ivan Jovanović.
- [Supporting radiotherapy patients](https://radexiorsboost.com/supporting-radiotherapy-patients/): We are proud of RadExIORSBoost team member Dr. Katarina Kopčalić, who delivered a lecture "The most frequently asked questions of patients treated with radiotherapy" on 29 October 2025 at the Ilija Kolarac Foundation. The event was organized in cooperation with the Serbian Society for the Fight against Cancer, aiming to clarify patients’ doubts about radiation therapy in an informal and open atmosphere.
- [Administrative visit of the RadExIORSBooost team members to Institute of Oncology Ljubljana](https://radexiorsboost.com/administrative-visit-of-the-radexiorsbooost-team-members-to-institute-of-oncology-ljubljana/): From 13 to 17 October 2025, Dr. Tatjana Stanojković, Dr. Ivana Matić, and Dr. Nina Petrović, the RadExIORSBoost project team members from the Institute for Oncology and Radiology of Serbia (IORS), visited the project team members and administrative staff from the Institute of Oncology Ljubljana. During the administrative visit, Dr. Stanojković, Dr. Matić, and Dr. Petrović participated in very successful and productive meetings with colleagues from the Public Procurement and Purchasing Department, Legal Department, Financial Department, and Human Resources Department at the Institute of Oncology Ljubljana. Prof. Dr. Maja Čemažar provided an excellent and comprehensive overview of the organizational structure and activities of the Research and Education Department of the Institute of Oncology Ljubljana, in addition to valuable guidance on managing national and EU-funded projects. Alma Čerin also shared with the IORS team members her knowledge and expertise in EU project administration. Very successful administrative visit of the RadExIORSBoost project team members from IORS significantly enhanced their knowledge in  administrative and project management.
- [RadExIORSBoost Project Workshop 2, Workshop 3, and Training 4 , 13-15 October 2025, Ljubljana, Slovenia](https://radexiorsboost.com/radexiorsboost-project-workshop-2-workshop-3-and-training-4-13-15-october-2025-ljubljana-slovenia/): RadExIORSBoost project team members participated in Workshop 2 "Radiosensitivity of malignant tumors", Workshop 3 entitled "Radioimmune staining", and Training 4 held from 13 to 15 October 2025 in Ljubljana and organized by the project team from the Institute of Oncology Ljubljana. The event brought together team members from the Institute for Oncology and Radiology of Serbia, Medical Faculty Mannheim, Heidelberg University, University of Leicester, and host Institute of Oncology Ljubljana. Prof. Dr. Maja Čemažar welcomed the RadExIORSBoost team members at the opening.
- [RadExIORSBoost team members at the 1st Regional SDIR-HDIR-MOKAD Congress and the 7th Congress of SDIR](https://radexiorsboost.com/radexiorsboost-team-members-at-the-1st-regional-sdir-hdir-mokad-congress-and-the-7th-congress-of-sdir/): RadExIORSBoost team members Ivana Matić, Nina Petrović, Irina Besu, Nađa Grozdanić Stanisavljević, and Maja Petrović  attended the 1st Regional SDIR-HDIR-MOKAD Congress and the 7th Congress of SDIR in Belgrade, held on 8-10 October 2025, as part of the Scientific and Organizing Committee. At this international congress, they successfully presented the RadExIORSBoost Twinning Horizon Europe Project at the Projects Hub, setting the stage for further scientific collaborations.
- [RadExIORSBoost team at the Hadron Therapy Symposium](https://radexiorsboost.com/radexiorsboost-team-at-the-hadron-therapy-symposium/): Dr. Tatjana Stanojković, Principal Research Fellow, and Prof. Dr. Marina Nikitović, attended the Hadron Therapy Symposium at the National Center for Oncological Hadrontherapy, CNAO, held in Pavia, Italy, on 5-8 October 2025. Prof. Dr. Marina Nikitović was invited to present the activities of the radiobiology research group at the Institute for Oncology and Radiology of Serbia, as well as the main activities within the Horizon Europe RadExIORSBoost project.
- [Administrative visit of the RadExIORSBooost team members to University of Leicester](https://radexiorsboost.com/administrative-visit-of-the-radexiorsbooost-team-members-to-university-of-leicester/): RadExIORSBoost team members Dr. Ivana Matić and Dr. Nina Petrović, from the Institute for Oncology and Radiology of Serbia (IORS), visited the project team from the University of Leicester, led by Prof. Dr. Christopher Talbot, from 29 September 2025 to 3 October 2025, as part of the project’s administrative visit. Team members from the University of Leicester and colleagues from the Research and Enterprise Division kindly welcomed Dr. Matić and Dr. Petrović, sharing their valuable knowledge and immense expertise in administration, pre-award, and post-award project management. The IORS team members visited the Department of Genetics, Genomics and Cancer Sciences, Research and Enterprise Division, Hope Cancer Trials Centre, Leicester Molecular Diagnostics and the NIHR Biomedical Research Centre, as well as Radiotherapy at University Hospitals of Leicester NHS Trust. The meetings organized at the University of Leicester helped the RadExIORSBoost project team members to gain new knowledge in sample and data management, and valuable insights into organizational structure of research and educational institution. Cutting-edge knowledge and expertise exchange between the RadExIORSBoost team from the University of Leicester and the team from the IORS will for sure strengthen the administrative, project management, and research capacities of the Institute for Oncology and Radiology of Serbia.
- [Radiogenomics Consortium Annual Meeting – September 15-16, 2025, Barcelona](https://radexiorsboost.com/radiogenomics-consortium-annual-meeting-september-15-16-2025-barcelona/): The RadExIORSBoost project team is very proud to share that Dr. Ivana Matić, the coordinator of the RadExIORSBoost project, was an invited speaker at the Radiogenomics Consortium Annual Meeting at the Vall d'Hebron Institute of Oncology, Barcelona Hospital, on 15-16 September 2025. Dr Matić presented the project goals and main project activities in the Session EU initiatives. Project team members, Prof. Dr. Christopher Talbot, Prof. Dr. Carsten Herskind, and Dr. Adam Webb also had presentations at the RGC Annual Meeting. 
- [Expert visit of Professor Dr. Sarah Kerns to Institute for Oncology and Radiology of Serbia](https://radexiorsboost.com/expert-visit-of-professor-dr-sarah-kerns-to-institute-for-oncology-and-radiology-of-serbia/): The RadExIORSBoost project team was honored to host Professor Dr. Sarah Kerns, distinguished expert in radiogenomics and radiobiology, from the Department of Radiation Oncology, Medical College of Wisconsin, United States of America. Her research projects are focused on inherited genetic variants and other biological factors related to normal tissue reactions in cancer patients receiving radiation therapy and the development of machine learning- based predictive models for a personalized radiotherapy approach. She is one of the two lead coordinators of the international Radiogenomics Consortium.
Prof. Kerns visited the Institute for Oncology and Radiology of Serbia from 26 August 2025 to 30 August 2025. A major highlight of the expert visit was Prof.  Kerns's lecture, titled "Genetic Risk Scores for the Prediction of Late Radiation Toxicity in Prostate Cancer". The outstanding  lecture held on 27 August 2025 at the IORS amphitheatre provided a valuable insights into her research in the field of radiogenomics and sparked a valuable discussions. Prof. Kerns visited the facilities and infrastructure of the Department for Radiotherapy of Solid Tumors and the Department of Experimental Oncology.  Her expert visit was an excellent opportunity for the RadExIORSBoost project team members to present ongoing project activities, share research findings, and discuss cutting-edge scientific approaches and advances in radiogenomics and radiobiology with Prof. Kerns. This collaboration represents a significant step towards boosting the IORS team's research potential and scientific excellence in radiobiology and molecular radiation oncology.
The RadExIORSBoost project team would like to express sincere gratitude to Prof. Sarah Kerns for sharing her scientific knowledge, immense expertise in radiogenomics, and vision with us.
- [Professor  Dr. sc. med. Marina Nikitović – Editor of the newly released textbook “Clinical Oncology and Radiotherapy”](https://radexiorsboost.com/professor-dr-sc-med-marina-nikitovic-editor-of-the-newly-released-textbook-clinical-oncology-and-radiotherapy/): We are pleased to highlight a significant academic achievement by Full Professor Dr. sc. med. Marina Nikitović, a distinguished member and Working Group Leader within our RadExIORSBoost Twinning Horizon Europe Project.
- [Dr. Katarina Kopčalić attended the Uro-Oncology OMI seminar in Salzburg, Austria](https://radexiorsboost.com/dr-katarina-kopcalic-attended-the-uro-oncology-omi-seminar-in-salzburg-austria/): Our project team member, Dr. Katarina Kopčalić, MD, PhD, radiation oncologist, attended the Uro-Oncology OMI seminar in Salzburg, Austria, from July 6 to July 12, 2025, with colleagues from various countries. During the seminar, eminent lecturers from Memorial Sloan Kettering Cancer Center generously shared their experiences from daily clinical practice and current protocols for treating uro-oncological malignancies. It was a great opportunity for our team member to gain and exchange knowledge in the field of prostate, bladder, kidney, and testicle cancer treatment.
- [RadExIORSBoost Project Training  “Genotoxicity testing in vitro and in humans” 25-26 June 2025, Center for Cancer Research, Medical University of Vienna](https://radexiorsboost.com/radexiorsboost-project-training-genotoxicity-testing-in-vitro-and-in-humans-25-26-june-2025-center-for-cancer-research-medical-university-of-vienna/): The RadExIORSBoost project is pleased to share details about the "Genotoxicity testing in vitro and in humans" training, which took place on June 25-26, 2025, at the Center for Cancer Research, Medical University of Vienna, Austria. The entire RadExIORSBoost project team, comprising members from all partner institutions including the Institute for Oncology and Radiology of Serbia, Medical Faculty Mannheim, Medical University of Vienna, Institute of Oncology Ljubljana, and University of Leicester, actively participated.This training, which focused on genotoxicity and investigation of DNA damage, was a crucial component of the comprehensive training program of the RadExIORSBoost project.
- [Short-term training visit of the IORS team members at Center for Cancer Research, Medical University of Vienna](https://radexiorsboost.com/short-term-training-visit-of-the-iors-team-members-at-center-for-cancer-research-medical-university-of-vienna/): Our project team members, PhD students Ivana Pašić and Maja Petrović, participated in a two-week scientific training program at the Center for Cancer Research at the Medical University of Vienna (MUW), from June 23 to July 4, 2025, as part of the RadExIORSBoost project. This experience was rewarding, providing hands-on work, inspiring discussions, and new insights into genotoxicity. The short-term visit provided IORS team members an opportunity to collaborate with a dedicated and welcoming team from the Center for Cancer Research. They deepen their knowledge through practical training, meaningful idea exchanges, and experimental setup ideas for genotoxicity testing. During this visit, Ivana and Maja performed the comet assay, a versatile method for detecting DNA damage in individual cells. They completed all steps of the alkaline comet assay, also known as single cell gel electrophoresis assay, from preparing the slides and embedding the cells into low-melting-point agarose to conducting electrophoresis, evaluating the comets, and performing statistical analysis of the results.
- [The Second RadExIORSBoost Educational Seminar for cancer patients treated with radiotherapy](https://radexiorsboost.com/the-second-radexiorsboost-educational-seminar-for-cancer-patients-treated-with-radiotherapy/): The RadExIORSBoost Horizon Europe Project team was pleased to organize the second educational seminar for patients with malignant diseases titled "Personalized approach in radiotherapy: From science to the clinic" held in the new amphitheater of the Institute for Oncology and Radiology of Serbia on June 17, 2025. Cancer patients actively participated and had the opportunity to ask and hear more about radiation therapy techniques, possible side effects, radiobiology and the response to radiation from the aspect of molecular and cellular biology, psychological support that is always available to them, the history and activities of the Serbian Society for the Fight Against Cancer, which is available to all citizens.
- [RadEXIORSBoost project team in a visit to the elementary school “Josif Pančić”](https://radexiorsboost.com/radexiorsboost-project-team-in-a-visit-to-the-elementary-school-josif-pancic/): As the end of the school year is approaching, on Tuesday, June 10, 2025, the RadExIORSBoost project team visited the elementary school "Josif Pančić", which has achieved great success at biology competitions during past years and has a long-lasting tradition of providing high-quality education. The team presented project activities to the pupils, who actively participated with great enthusiasm and asked many interesting questions. The team members dr Ivana Matić, dr Tatjana Stanojković, dr Katarina Kopčalić, dr Aleksandar Stepanović, and dr Nina Petrović talked about types of radiation, environmental exposure, biological response to irradiation, radiotherapy, and molecular biology techniques for investigating individual radiosensitivity. It was a great pleasure to share and exchange knowledge in radiobiology with such enthusiastic pupils and their teacher. The project team members emphasized the importance of teamwork for the achievements in science and medicine.
- [RadExIORSBoost Team Members Participation in International Workshop “Use of Genotoxicity Methods for Human Biomonitoring: Prevention – Diagnosis and Therapy of Cancer”](https://radexiorsboost.com/radexiorsboost-team-members-participation-in-international-workshop-use-of-genotoxicity-methods-for-human-biomonitoring-prevention-diagnosis-and-therapy-of-cancer/): Members of the RadExIORSBoost project team, Prof. Dr. Siegfried Knasmüller, Dr. Miroslav Mišík, and Dr. Ivana Matić, delivered impactful lectures at the international workshop "Use of Genotoxicity Methods for Human Biomonitoring: Prevention – Diagnosis and Therapy of Cancer", held on June 6, 2025, at AKH in Vienna.  This workshop was organized as a satellite event of the 53rd Congress of the European Environmental Mutagenesis and Genomics Society (EEMGS) by Prof. Dr. Siegfried Knasmüller, Dr. Miroslav Mišík, and Dr. Georg Wultsch. The event brought together leading international experts in genotoxicology and human biomonitoring to discuss research and possible clinical applications.
- [Short-term training visit of IORS team members at Medical Faculty Mannheim](https://radexiorsboost.com/short-term-training-visit-of-iors-team-members-at-medical-faculty-mannheim/): Members of the RadExIORSBoost project team and IORS PhD students,  Ivana Pašić and Maja Petrović, participated in a short-term visit to the Medical Faculty Mannheim, Heidelberg University from 12 May to 24 May 2025. During their visit, they gained practical experience in a range of radiobiology techniques, such as magnetic separation as CD4+ and CD8+ T cells, followed by RNA isolation, assessing RNA integrity and quality, preparing samples for RNA sequencing and RNA-Seq pipeline analysis, conducting the Radiation-Induced Lymphocyte Apoptosis (RILA) assay, and analyzing RILA data using FlowJo software. They also conducted the Colony Formation Assay (CFA) and performed related calculations. Their visit featured a series of lectures and discussions on cutting-edge radiotherapy techniques and the latest approaches and advancements in radiobiology research. This valuable experience was made possible by Prof. Dr. Carsten Herskind, Prof. Dr. Marlon Veldwijk, Ahmad Šami, and Tijana Vlatković, and it concluded with the acquisition of numerous new skills.
- [Administrative visit of the RadExIORSBoost project team members – Medical Faculty Mannheim, Heidelberg University, May 2025](https://radexiorsboost.com/administrative-visit-of-the-radexiorsboost-project-team-members-medical-faculty-mannheim-heidelberg-university-may-2025/): During their administrative visit, Dr. Tatjana Stanojković, Dr. Ivana Matić, and Dr. Nina Petrović visited the Heidelberg University Research Service and Medical Faculty Mannheim on 13 May 2025 at the Central University Administration in Heidelberg. The RadExIORSBoost project team members from IORS and Prof. Dr. Carsten Herskind from UMM were kindly welcomed by Dr. Moritz Vogel, Research Manager for EU & Internationales, and Dr. Ralf Weigel, Research Support Officer. They presented pre- and post-award research services and support in addition to EU funded project management and administration. On Thursday, May 15, 2025, the RadExIORSBoost project team members from IORS and Prof. Dr. Marlon Veldwijk from UMM, participated in a very successful and insightful meeting with PD Dr. med. Elena Sperk, Managing Director of the Study Center of the Mannheim Cancer Center, along with her team members, Dr. med. Daniel Buergy and Angelika Puzowski. Dr. Elena Sperk provided an excellent and valuable overview of the organizational structure, services, and activities of her Management team and the Mannheim Cancer Center.
- [RadExIORSBoost Training Visit 2 “State of the art radiotherapy techniques and radiobiology research at the UMM” 13-14 May 2025  – Universitätsmedizin Mannheim (UMM)](https://radexiorsboost.com/radexiorsboost-training-visit-2-state-of-the-art-radiotherapy-techniques-and-radiobiology-research-at-the-umm-13-14-may-2025-universitatsmedizin-mannheim-umm/): The second RadExIORSBoost project training titled “State of the art radiotherapy techniques and radiobiology research at the UMM" was successfully held on May 13-14, 2025, at the UMM. Members of the RadExIORSBoost project team from the Institute for Oncology and Radiology of Serbia, Institute of Oncology Ljubljana, and Medical University of Vienna visited the project team members from the Medical Faculty Mannheim, Heidelberg University. The training gathered 18 project team members.
- [Dr Nina Petrović held a lecture at the Stem Cell Research Center (KÖKMER) of Ondokuz Mayıs University  – 09 May 2025](https://radexiorsboost.com/dr-nina-petrovic-held-a-lecture-at-the-stem-cell-research-center-kokmer-of-ondokuz-mayis-university-09-may-2025/): We are pleased to share that the RadExIORSBoost project team member Senior Research Associate Dr Nina Petrović was an invited speaker at the Stem Cell Research Center (KÖKMER) of Ondokuz Mayıs University, Samsun, Turkey. Her online lecture entitled "Radiotherapy-induced adverse effects: from genome and transcriptome analysis to individual patients' radiosensitivity prediction." was organized by Doç. Dr. Sercan Ergün who kindly introduced her talk to the scientific audience. On Dr Petrović successfully presented the RadExIORSBoost project activities.
- [Defense of PhD thesis Katarina Kopčalić 23.04.2025.](https://radexiorsboost.com/defense-of-phd-thesis-katarina-kopcalic-23-04-2025/): It is an honor to share an outstanding PhD thesis defense of the RadExIORSBoost team member dr Katarina Kopčalić. Katarina successfully defended her PhD thesis titled “Predictive significance of clinical characteristics and molecular biomarkers for the occurrence of toxicity during and after radiotherapy in prostate cancer patients” at the Faculty of Medicine - University of Belgrade on 23 April 2025.
- [Prof. Dr.sc. med. Marina Nikitović participated in the session “Update of Protocols for Prostate Cancer Radiotherapy” at Radiotherapy Section in Kragujevac](https://radexiorsboost.com/prof-dr-sc-med-marina-nikitovic-participated-in-the-session-update-of-protocols-for-prostate-cancer-radiotherapy-at-radiotherapy-section-in-kragujevac/): On March 28, 2025, the Radiotherapy Section was successfully held in Kragujevac, during which Prof. Dr. sc. med. Marina Nikitović participated as a panelist in the session "Update of Protocols for Prostate Cancer Radiotherapy."
- [Expert visit of Professor Prof. Dr. Siegfried Knasmüller](https://radexiorsboost.com/expert-visit-of-professor-prof-dr-siegfried-knasmuller/): Prof. Dr. Siegfried Knasmüller, a well-known and eminent expert in the field of genetic toxicology, and the RadExIORSBoost project member visited the team at the Institute for Oncology and Radiology of Serbia from 13 April 2025 to 17 April 2025.  Prof. Knasmüller is the Head of the Environmental Toxicology Group at the Center for Cancer Research, Medical University of Vienna. The main research work of his group is focused on the assessment of induction of DNA damage and cancer by dietary, lifestyle, and occupational factors, as well as the detection of environmental mutagens. He participated in international and EU research projects, many national projects, and industrial studies. Prof. Knasmüller is the Editor-in-Chief of the journal Mutation Research and co-editor of Food and Chemical Toxicology. His research group published more than 250 highly-cited scientific publications.
- [Administrative staff visit – RadExIORSBoost project team hosted Mrs. Marie Adams and Dr. Colin Veal](https://radexiorsboost.com/administrative-staff-visit-radexiorsboost-project-team-hosted-mrs-marie-adams-and-dr-colin-veal/): Mrs. Marie Adams, Head of Research and Partnership Development, Research and Enterprise Division, and Dr. Colin Veal, Research and Partnership Development Manager at the University of Leicester, United Kingdom, visited the Institute for Oncology and Radiology of Serbia on 2 April 2025 and 3 April 2025. This visit was a part of the RadExIORSBoost project administrative staff visit between two project partner institutions.  During their visit, Mrs. Adams and Dr. Veal have shared their valuable expertise in project management, research collaboration and partnership support.  They highlighted the importance of multidisciplinary project supervision to gain adequate skills for successful application and project implementation in various research fields. The structure of the University of Leicester was presented to IORS members, as well as the insights into processes of pre- and post-award managing and implementation. Future directions were discussed and researchers were encouraged and trained on how to prepare the "Rulebook for successful project and research management" to attract new research funding.
- [Expert visit of Professor Dr. Maja Čemažar to Institute for Oncology and Radiology of Serbia](https://radexiorsboost.com/expert-visit-of-professor-dr-maja-cemazar-to-institute-for-oncology-and-radiology-of-serbia/): Prof. Dr. Maja Čemažar, a distinguished expert and member of the RadExIORSBoost project team, visited the Institute for Oncology and Radiology of Serbia from 31 March 2025 to 4 April 2025. She is the Head of the Research and Education Division at the Institute of Oncology Ljubljana, Slovenia, the Head of the Department of Experimental Oncology, and a full professor at the Faculty of Health Sciences, University of Primorska. Prof. Čemažar’s main research interest is in the field of gene electrotransfer and gene therapy. She is the author of more than 350 scientific publications. 
- [The RadExIORSBoost Educational seminar for cancer patients treated with radiotherapy](https://radexiorsboost.com/the-radexiorsboost-educational-seminar-for-cancer-patients-treated-with-radiotherapy/): Embracing the first day of spring, on March 20, 2025, the RadExIORSBoost team organized an educational seminar for patients with cancer titled "Personalized Approach in Radiotherapy: From Science to Clinic" at the Palace of Science in Belgrade. The seminar was organized in collaboration with the Serbian Society for the Fight Against Cancer and the Working Group for Patient Support of the Institute for Oncology and Radiology of Serbia. The seminar provided a welcoming and pleasant environment where patients had the opportunity to learn about the basic principles and the importance of radiotherapy, as well as recommendations that should be followed during radiotherapy. The opening speech was held by dr sc. Ivana Matić, the RadExIORSBoost project leader and Doc. dr sc. med. Milan Žegarac, the director of the Institute for Oncology and Radiology of Serbia. The sessions were chaired by Prof. dr sc. med. Marina Nikitović, and principal research fellow dr sc. Tatjana Stanojković. Dr sc. med. Aleksandar Stepanović presented modern radiotherapy approaches in the treatment of cancer patients, Dr Jelena Stanić talked about the adverse effects of radiotherapy, while Dr Katarina Kopčalić answered the most common questions related to cancer radiotherapy. Dr sc. Ivana Matić held a lecture about biological factors for the prediction of individual radiosensitivity and presented the main research concepts and goals of the RadExIORSBoost project. Dr sc. med. Marija Andrijić emphasized the importance of psychological support for cancer patients. The activities of the IORS Working Group for Patient Support were presented by Dr sc. med. Ana Jovićević, while Dr sc. Jelena Bokun, the president of the Serbian Society for the Fight Against Cancer, provided an overview of the society’s work.  
- [Expert visit of Professor Dr. Carsten Herskind](https://radexiorsboost.com/expert-visit-of-professor-dr-carsten-herskind/): The RadExIORSBoost Project team had the honor and privilege of hosting Prof. Dr. Carsten Herskind, a distinguishing expert in radiobiology who visited the IORS team from 16 March 2025 to 20 March 2025. Prof. Carsten Herskind is a project team member from the Cellular and Molecular Radiation Oncology Laboratory of the Department of Radiation Oncology at the Medical Faculty Mannheim, Heidelberg University. Prof. Carsten is the author of more than 100 publications focused mostly on radiosensitivity of cancer patients and radiation therapy; Genome Wide Association Study, as well as the normal tissue reactions to radiotherapy and patients’ quality of life. The research group of Prof. Herskind and Prof. Veldwijk has participated in several significant multi-institutional national and international projects.

## Pages
- [Promotional Video](https://radexiorsboost.com/promotional-video/): RadExIORSBoost
- [Gallery](https://radexiorsboost.com/gallery/): RadExIORSBoost
- [Contact](https://radexiorsboost.com/contact/): RadExIORSBoost
- [Consortium](https://radexiorsboost.com/consortium/): RadExIORSBoost
- [Work packages](https://radexiorsboost.com/work-packages/): RadExIORSBoost
- [Specific objectives](https://radexiorsboost.com/specific-objectives/): RadExIORSBoost
- [Summary](https://radexiorsboost.com/summary/): RadExIORSBoost
- [Home](https://radexiorsboost.com/): Prostate cancer patients receiving radiotherapy (RT) may develop radiation-induced side effects, which significantly impact quality of life.